"Overall, mice and humans share virtually the same set of genes. Almost every gene found in one species so far has been found in a closely related form in the other. Of the approximately 4,000 genes that have been studied, less than 10 are found in one species but not in the other." https://www.genome.gov/10001345/importance-of-mouse-genome
"One reason that mouse models might not completely mimic human disorders is that mice simply might not be capable of expressing some cognitive human disease symptoms that are apparent to the observer. For example, Huntington's disease patients show dyskinesia (involuntary movements), whereas mice do not."
Calling low glucose a "fad diet" is disingenuous. Every credible health organization in the world recommends reducing sugar intake. Sugar is directly linked to virtually all major non-communicable metabolic diseases. Limiting glucose is among the most effective and well-studied dietary interventions we have available.
Please, show me a single credible scientific study that recommends increasing or even holding steady our current levels of sugar consumption. Until then, I will listen to the research and reduce sugar. If it promotes new neuron growth, that's gravy on top but really beside the point.
Every remotely credible "fad diet" agrees with the science - sugar should be reduced or eliminated. They differ wildly in other details but none promote sugar. It's the closest thing we have to universally accepted dietary knowledge, there's really no controversy on the sugar question.
There's a PoV that sugar should be treated and thought more like a controlled substance [0]. I tend to agree. It has weak addictive properties and is used without restraint by the food industry to make more sales by transforming foods into a weak resemblance of candy.
"Once upon a time, sugar was a condiment. Now it’s a diet staple. That’s a problem, because as it turns out, we as human beings have a limited capacity to metabolize it. There are things you can do to up your metabolism, like vigorous exercise. But the bottom line is we have a limited capacity to metabolize it — virtually like every poison, kind of like alcohol. So a little is okay; a lot is not."
The class of drug is an antidote against Western Disease, addiction, etc by patching a reward center. Turns out refined sugar, HFCS, and such are poison.
Stop. This is in mice, and they state:
>> By knocking out Slc2a4 and reducing glucose influx, the aged stem cells became more likely to activate and produce new neurons.
They knocked out a gene, it was not glucose alone. Please understand this before joining the new fad diet train.
Article in Nature link:
https://www.nature.com/articles/s41586-024-07972-2
"Overall, mice and humans share virtually the same set of genes. Almost every gene found in one species so far has been found in a closely related form in the other. Of the approximately 4,000 genes that have been studied, less than 10 are found in one species but not in the other." https://www.genome.gov/10001345/importance-of-mouse-genome
Mice models are valuable, but...
"One reason that mouse models might not completely mimic human disorders is that mice simply might not be capable of expressing some cognitive human disease symptoms that are apparent to the observer. For example, Huntington's disease patients show dyskinesia (involuntary movements), whereas mice do not."
https://www.nature.com/scitable/topicpage/the-use-of-animal-...
Quitting sugar changes things ... Everything else tastes sweeter.
I did a 5 year stint of no sugar except for one cheat day a month.
My rules were: Fruit and milk OK No products with honey, sugar, high fructose corn syrup etc.
The first 2 weeks are the hardest then it is pretty easy to do...
Calling low glucose a "fad diet" is disingenuous. Every credible health organization in the world recommends reducing sugar intake. Sugar is directly linked to virtually all major non-communicable metabolic diseases. Limiting glucose is among the most effective and well-studied dietary interventions we have available.
Please, show me a single credible scientific study that recommends increasing or even holding steady our current levels of sugar consumption. Until then, I will listen to the research and reduce sugar. If it promotes new neuron growth, that's gravy on top but really beside the point.
I meant fad diets that people chase and name, not healthy personalized diets.
Every remotely credible "fad diet" agrees with the science - sugar should be reduced or eliminated. They differ wildly in other details but none promote sugar. It's the closest thing we have to universally accepted dietary knowledge, there's really no controversy on the sugar question.
Man, why you gotta be a kill joy
It's better than being a kill brain
How much does CRISPR cost nowadays, anyways?
If you want to start off mucking around with yeast, < $300 USD according to this [1] (or < $200 if you want the non-flourescent version).
[1] https://www.the-odin.com/genet/
There's a PoV that sugar should be treated and thought more like a controlled substance [0]. I tend to agree. It has weak addictive properties and is used without restraint by the food industry to make more sales by transforming foods into a weak resemblance of candy.
"Once upon a time, sugar was a condiment. Now it’s a diet staple. That’s a problem, because as it turns out, we as human beings have a limited capacity to metabolize it. There are things you can do to up your metabolism, like vigorous exercise. But the bottom line is we have a limited capacity to metabolize it — virtually like every poison, kind of like alcohol. So a little is okay; a lot is not."
[0] https://www.vox.com/2014/6/2/5771008/the-case-for-treating-s...
The fasting and keto folks were right!
Another win for GLP-1s
That's the latest flavour-of-the-week LLM model right?
https://en.wikipedia.org/wiki/Semaglutide
The class of drug is an antidote against Western Disease, addiction, etc by patching a reward center. Turns out refined sugar, HFCS, and such are poison.
https://en.wikipedia.org/wiki/Diseases_of_affluence
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